Advancing Care for
Primary Biliary Cholangitis (PBC)

Explore innovative therapies for managing PBC through clinical trials.

What is
Primary Biliary Cholangitis (PBC)?

Primary Biliary Cholangitis (PBC) is a chronic autoimmune condition that causes gradual damage to the bile ducts in the liver. Over time, bile builds up in the liver, leading to inflammation, scarring, and potentially cirrhosis. This condition primarily affects middle-aged women but can occur in men and younger individuals.

Key Symptoms of PBC:

  • Persistent fatigue
  • Itching (pruritus)
  • Abdominal pain
  • Dry eyes and mouth
  • Jaundice (yellowing of the skin and eyes in later stages)

PBC is often diagnosed through routine blood tests showing elevated liver enzymes or markers of autoimmunity, such as anti-mitochondrial antibodies (AMAs).

Free Liver Scanning for Early Detection

Protect Your Liver, Protect Your Health

Coastal Research offers free, non-invasive liver scans to detect early signs of fatty liver disease.
If you have unexplained fatigue, abdominal discomfort, or elevated liver enzymes, get valuable health insights at no cost.

Why Participate in a PBC Clinical Trial?

Participating in a clinical trial allows you to access cutting-edge treatments while contributing to the advancement of medical research for PBC. Benefits include:

  • Early Access to Investigational Therapies: New treatments aimed at slowing disease progression and managing symptoms.
  • Comprehensive Care: Monitoring and support from a dedicated team of specialists.
  • No Cost to You: All trial-related tests, medications, and consultations are provided free
    of charge.

Current Treatment Landscape for PBC

While there is no cure for PBC, available treatments focus on slowing disease progression, improving symptoms, and preventing complications.

Standard Treatments Include:

  • Ursodeoxycholic Acid (UDCA): The first-line therapy to improve bile flow and reduce
    liver damage.
  • Obeticholic Acid (OCA): A second-line option for patients who do not respond adequately to UDCA.


Emerging therapies in clinical trials aim to address inflammation, bile flow, and fibrosis more
effectively, offering hope for improved outcomes.

Clinical Trials at Coastal Research Institute

At Coastal Research Institute, we are conducting trials for innovative PBC therapies that focus on:

  • Reducing liver inflammation.
  • Slowing or halting disease progression.
  • Improving quality of life for individuals living with PBC.


Our trials are designed to prioritize patient safety and comfort while advancing care for this chronic condition.

How to Get Started

  1. Complete a simple pre-screening questionnaire to determine your eligibility.
  2. Meet with our research team to discuss trial details and ask questions.
  3. Begin your journey with comprehensive support and expert care throughout the trial process.

Interested in Participating?

Are you between the ages of 18-75 years old?
Have you ever been diagnosed with Fatty Liver Disease, Non Alcoholic Fatty Liver Disease (NAFLD), Hepatic Steatosis, or Steatohepatitis?
Have you ever been told you have any of the following conditions:
Are you overweight/obese?